Genomics, and above all metagenomics, constitute the sharpest method for studying interaction between skin and its microbiota, and analysis the entirety of the microorganism communities present on the epidermis.

Our analytical solutions for dermocosmetics

As a true scientific partner, GenoScreen provides the beauty and skin care sector with tailor-made solutions and high-performance tools that boost innovation :

Skin Microbiota

GenoBiome Skin, our all-in-one offer for analysing cutaneous microorganism communities

Microbiome friendly testing

Metagenomics with several adaptable technologies to shape your own projects : targeted metagenomics 16S (bacteria), 18S/ITS (fungi) in short read and long read, shotgun metagenomics from skin swab samples.

Research and regulatory compliance skin microbiome

Strain-specific solutions

Genomic tools for identifying, sequencing, annotating and comparing microbial genomes

Genotyping strains of interest (virulence detection)

Bacterial/fungal genes differential expression under varying conditions (with or without application of an active ingredient, for example), using Transcriptomics (RNA-Seq)

Microorganism strains quantification through qPCR approach

Expertise and know-how

Bioinformatics : customized pipeline developed by GenoScreen, interactive and comprehensive reports

Support from experts : from experimental protocol design to results interpretation, our team of microbiologists will provide you answers to you initial biological questions

Skincare claims validation and Regulatory dossiers fulfillment

Research and regulatory compliance skin microbiome

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Examples of GenoScreen involvement in R&D projects for Skin Care

Slide 1

Microbiome Modulation in Acne Patients and Clinical Correlations

https://doi.org/10.3390/life14060688

Ionescu M-A, Tatu AL, Busila C, Axente ER, Badalato N, Feuilloley MGJ, Asquier E, Martínez JD, Lefeuvre L. Microbiome Modulation in Acne Patients and Clinical Correlations. Life. 2024; 14(6):688.

Slide 2

Respect of Skin Microbiome with Different Types of LeavE-on Skincare Products, an Ecobiological Approach

https://doi.org/10.20944/preprints202005.0500.v1

Callejon, S., Giraud, F., Larue, F., Buisson, A., Matéos, L., Grare, L., Guyoux, A., Perrier, E., Ardiet, N., & Trompezinski, S. (2020). Respect of Skin Microbiome with Different Types of LeavE-on Skincare Products, an Ecobiological Approach. Preprints.

Slide 3

Effects of a New Emollient-Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis

https://doi.org/10.1111/pde.12786

Bianchi, P., Theunis, J., Casas, C., Villeneuve, C., Patrizi, A., Phulpin, C., Bacquey, A., Redoulès, D., Mengeaud, V., & Schmitt, A. M. (2016). Effects of a New Emollient-Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis. Pediatric dermatology, 33(2), 165–171.

Slide 4

Complete Genome Sequence of Staphylococcus epidermidis PH1-28, Isolated from the Forehead of a Hyperseborrheic Donor

https://doi.org/10.1128/MRA.00165-21

Hilaire, P., Landemaine, L., Contreras, S., Blanquart-Goudezeune, H., Siguier, P., Cornet, F., Chiapello, H., Loux, V., Clavaud, C., & Morand, S. C. (2021). Complete Genome Sequence of Staphylococcus epidermidis PH1-28, Isolated from the Forehead of a Hyperseborrheic Donor. Microbiology resource announcements, 10(9), e00165-21.

Slide 5

Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation

https://doi.org/10.3389/fimmu.2023.1098160

Landemaine, L., Da Costa, G., Fissier, E., Francis, C., Morand, S., Verbeke, J., Michel, M. L., Briandet, R., Sokol, H., Gueniche, A., Bernard, D., Chatel, J. M., Aguilar, L., Langella, P., Clavaud, C., & Richard, M. L. (2023). Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation. Frontiers in immunology, 14, 1098160.